Acemannan is an extract from aloe vera, a plant with a long history of traditional medicine usage for wound healing. Acemannan, an immune polysaccharide (sugar molecule), belongs to a group of biological response modifiers that interact with the receptors (cell communicators) on the surface of immune system cells, having a stimulatory effect.
Aloe vera has long been used as a traditional medicine for inducing wound healing. Findings suggest that acemannan plays a significant role in the oral wound healing process via the induction of fibroblast proliferation and stimulation of KGF-1, VEGF, and type I collagen expressions.(1)
Acemannan, a complex carbohydrate shown to stimulate interleukin-1, tumor necrosis factor alpha and prostaglandin E2 production by macrophages, has also demonstrated antiviral activity in vitro against human immunodeficiency virus, Newcastle disease virus and influenza virus. A pilot study was undertaken to determine acemannan’s effect in 49 feline immunodeficiency virus (FIV) infected cats. Results suggest that acemannan therapy may be of significant benefit in FIV-infected cats exhibiting clinical signs of disease.(2)
Following four to seven weekly acemannan treatments, tumor shrinkage occurred in four of 12 animals, with tumors accessible to measurement. A notable increase in necrosis and inflammation was observed. Acemannan Immunostimulant may be an effective adjunct to surgery and radiation therapy in the treatment of canine and feline fibrosarcomas.(3)
Biological response modifiers are large sugar molecules (immune polysaccharides), or sugar and protein molecules (glycoproteins) that interact with the receptors on the surface of immune system cells. These receptors coat the surface of every cell with a nucleus, helping to facilitate communication between cells. Glycoproteins and immune polysaccharides increase the ability of white blood cells (macrophages) to destroy infectious organisms and may possess bone marrow stimulating activity. They also help promote the destruction of solid tumors such as fibrosarcomas and have proven very useful in the treatment of immune deficiency disorders of cats such as feline leukemia virus (FeLV) infection and feline immunodeficiency (FIV) infection. Acemannan is an immune polysaccharide that it has been well researched and consistently found to improve immune function in a variety of disorders. Ample evidence also supports the use of acemannan in the treatment of cancer. In a study of its use in fibro-sa rcoma, 50% of animals treated with weekly acemannan injections demonstrated tumor shrinkage and necrosis.(4)
Acemannan Research Sources
AV Ace-Immune is a bioavailable acemannan dietary supplement. Each serving of AV Ace-Immune Powder contains 2.6 grams of aloe vera extract (the source of acemannan). Acemannan works well in conjunction with other anti-cancer pet products such as Hydrazine Sulfate and Cesium Chloride.
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