Hydrazine Sulfate is a dietary supplement available liquid and capsule form. Hydrazine Sulfate was first proposed as an anticachexia agent based on its inhibition of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEP CK). In other words, it can inhibit a key enzyme necessary for the production of glucose from lactic acid, thereby potentially short-circuiting the cachexia process. Excess lactic acid that is not being converted to glucose can be excreted by the kidneys.
Cancer cells consume massive amounts of glucose, which consumes energy. They process the glucose with fermination, which is very inefficient. A byproduct of this fermentation is lactic acid. This lactic acid then goes into the liver. The liver then converts this lactic acid back into glucose, consuming even more energy. Much of this glucose is consumed by the cancer cells and the cycle starts over.
Dr. Joseph Gold, founder of the Syracuse Cancer Research Institute (SCRI), researched cancer cachexia. Dr. Gold’s theory was that if the conversion process that cancer cells use to recycle and reuse their own waste products could be interrupted, this altered metabolism could be normalized and cancer cachexia could be reversed. Dr. Gold’s research at SCRI lead to the discovery of the “gluconeogenic blocking agent” Hydrazine Sulfate which could shut down the liver enzyme necessary for gluconeogenesis through the Cori cycle.
According to the Syracuse Cancer Research Institute (SCRI), which for the past 20 years has collected reports from thousands of doctors, veterinarians, and individuals using hydrazine sulfate, the following results have been observed: 50% measurable symptomatic improvement, 40% tumor stabilization or regression, 5%-10% long term “complete response,” i.e., survival.
Cachexia in Pets
Cancer wasting is especially difficult in pets. When a pet stops eating, they can quickly lose energy and begin to lose their will to live. Enticing a pet to eat can become ever increasingly more difficult situation. In pets, Hydrazine Sulfate has been used as an appetite stimulant. If you can get a pet to eat, it will greatly help keep up their energy levels and improve their quality of life. Serving size in pets varies greatly by weight. Very large dogs may use a normal adult serving size, but cats and small dogs will use a much smaller serving size. For pets, the liquid form of Hydrazine Sulfate is by far the easiest to use. It is practically tasteless and can be quickly administered with a syringe or a small eyedropper.
Cachexia Treatment Sources
Hydrazine Sulfate Research
The Syracuse Cancer Research Institute(SCRI) is a charitable, educational and scientific organization whose major purpose is the performance of laboratory and clinical cancer research aimed toward the innovation of new, effective treatments for cancer and the dissemination of its scientific findings and discoveries, in particular the development, clinical use, and clinical results of hydrazine sulfate. SCRI is involved in the research of Hydrazine Sulfate. They will answer questions on dosage and contraindications for pets most weekdays from 9 AM to 5 PM EST.
Hydrazine Sulfate Research Sources
Where can I purchase Hydrazine Sulfate
There are many sources to purchase powdered Hydrazine Sulfate but in our experience, liquid is the easiest form for getting the correct dosage and administering to pets. It is also flavorless and can easily be added to your pets food.